[HTML][HTML] Possible Role for Intracellular Cholesteryl Ester Transfer Protein in Adipocyte Lipid Metabolism and Storage*♦
L Izem, RE Morton - Journal of Biological Chemistry, 2007 - ASBMB
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester (CE) and triglyceride
(TG) between lipoproteins in plasma. However, short term suppression of CETP
biosynthesis in cells alters cellular cholesterol homeostasis, demonstrating an intracellular
role for CETP as well. The consequences of chronic CETP deficiency in lipid-storing cells
normally expressing CETP have not been reported. Here, SW872 adipocytes stably
expressing antisense CETP cDNA and synthesizing 20% of normal CETP were created …
(TG) between lipoproteins in plasma. However, short term suppression of CETP
biosynthesis in cells alters cellular cholesterol homeostasis, demonstrating an intracellular
role for CETP as well. The consequences of chronic CETP deficiency in lipid-storing cells
normally expressing CETP have not been reported. Here, SW872 adipocytes stably
expressing antisense CETP cDNA and synthesizing 20% of normal CETP were created …
